Understanding Ankylosing Spondylitis: Causes and Mechanisms
Step 1: Genetic Predisposition Step 2: Triggering Factors (Environmental & Microbial) Step 3: Immune Activation Step 4: Inflammation of Entheses (Enthesitis) Step 5: Structural Damage & Bone Erosion Step 6: Pathologic New Bone Formation Step 7: Axial & Extraspinal Manifestations 🧠Summary Flow (Layman-Friendly): Genetic Risk (like HLA-B27)⬇Trigger from Gut Bacteria or Injury⬇Immune System Overreacts⬇Inflammation…